We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Household Income Is Associated with the p53 Mutation Frequency in Human Breast Tumors.
- Authors
Starks, Adrienne M.; Martin, Damali N.; Dorsey, Tiffany H.; Boersma, Brenda J.; Wallace, Tiffany A.; Ambs, Stefan
- Abstract
Background: A study from Scotland reported that the p53 mutation frequency in breast tumors is associated with socio-economic deprivation. Methods: We analyzed the association of the tumor p53 mutational status with tumor characteristics, education, and self-reported annual household income (HI) among 173 breast cancer patients from the greater Baltimore area, United States. Results: p53 mutational frequency was significantly associated with HI. Patients with < $15,000 HI had the highest p53 mutation frequency (21%), followed by the income group between $15,000 and $60,000 (18%), while those above $60,000 HI had the fewest mutations (5%). When dichotomized at $60,000, 26 out of 135 patients in the low income category had acquired a p53 mutation, while only 2 out of 38 with a high income carried a mutation (P < 0.05). In the adjusted logistic regression analysis with 3 income categories (trend test), the association between HI and p53 mutational status was independent of tumor characteristics, age, race/ethnicity, tobacco smoking and body mass. Further analyses revealed that HI may impact the p53 mutational frequency preferentially in patients who develop an estrogen receptor (ER)-negative disease. Within this group, 42% of the low income patients (< $15,000 HI) carried a mutation, followed by the middle income group (21%), while those above $60,000 HI did not carry mutations (Ptrend < 0.05). Conclusions:: HI is associated with the p53 mutational frequency in patients who develop an ER-negative disease. Furthermore, high income patients may acquire fewer p53 mutations than other patients, suggesting that lifetime exposures associated with socio-economic status may impact breast cancer biology.
- Subjects
INCOME; P53 antioncogene; GENETIC mutation; BREAST cancer; SOCIOECONOMIC factors; MEDICAL economics; EPIDEMIOLOGY
- Publication
PLoS ONE, 2013, Vol 8, Issue 3, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0057361