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- Title
Beneficial effects of perospirone on aggressive behavior associated with dementia.
- Authors
SATO, SHINJI; MIZUKAMI, KATSUYOSHI; MORO, KAZUO; TANAKA, YOSHIRO; ASADA, TAKASHI
- Abstract
The aim of this study was to assess the efficacy of the serotonin-dopamine antagonist perospirone in treating aggressive and agitated behavior in patients with dementia. Six patients were referred to the outpatient clinic of Ishizaki Hospital and were followed for 6 weeks. Their psychiatric diagnoses were made using the DSM-IV. Their behavioral symptoms and degrees of cognitive impairment were measured using the Behavioral Pathology in Alzheimer's Disease (BEHAVE-AD) and the Mini-Mental Examination State. The changes in BEHAVE-AD scores were investigated. Maximum benefit was achieved at a mean perospirone dose of 9.0 mg/day. No patient experienced severe adverse effects. Post-hoc analysis showed significant improvement in the total BEHAVE-AD and aggressiveness subscale scores within 2 weeks. This study suggests that perospirone is effective in improving aggressive and agitated behavioral symptoms in demented patients and is safe to use in elderly patients.
- Subjects
AGGRESSION (Psychology); DEMENTIA; DISEASES in older people; NEUROSES in old age; SYMPTOMS; DOPAMINE antagonists; SEROTONIN antagonists
- Publication
Psychiatry & Clinical Neurosciences, 2006, Vol 60, Issue 1, p106
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1111/j.1440-1819.2006.01467.x