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- Title
Study of analgesic effect of earthworm extract.
- Authors
Wei Luo; Zhen-han Deng; Rui Li; Guo Cheng; Kotian, Ronak Naveenchandra; Yu-sheng Li; Wen-ping Li
- Abstract
Pain represents a major clinical problem and one which has exercised generations of healthcare professionals. Earthworms are used as a traditional Chinese medicine, and have been applied pharmacologically and clinically since a long time in China. However, the analgesic effects of earthworm extract (EE) are seldom studied. Hence, we evaluated the analgesic effects of EE inmice. The obtained data showed that EE increased pain threshold and exhibited peripheral but not central analgesic effects in mice; evidenced by increased inhibition ratio in acetic acid writhing test and formalin test, whereas only slight increase in inhibition ratio in hot plate test and tail immersion test. In addition, EE decreased serum norepinephrine (NE), 5-hydroxytryptamine (5-HT), and nitric oxide (NO) synthase (NOS) concentration, similar to other analgesic drugs like morphine and aspirin. In a nutshell, the obtained data have demonstrated that EE has peripheral analgesic properties and could be used as a promising analgesic drug.
- Subjects
EARTHWORMS; MEDICAL care; PHARMACOLOGY; ACETIC acid; NITRIC oxide
- Publication
Bioscience Reports, 2018, Vol 38, Issue 1, p1
- ISSN
0144-8463
- Publication type
Article
- DOI
10.1042/BSR20171554