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- Title
High density lipoprotein cholesterol: an evolving target of therapy in the management of cardiovascular disease.
- Authors
Kapur NK; Ashen D; Blumenthal RS; Kapur, Navin K; Ashen, Dominique; Blumenthal, Roger S
- Abstract
Since the pioneering work of John Gofman in the 1950s, our understanding of high density lipoprotein cholesterol (HDL-C) and its relationship to coronary heart disease (CHD) has grown substantially. Numerous clinical trials since the Framingham Study in 1977 have demonstrated an inverse relationship between HDL-C and one's risk of developing CHD. Over the past two decades, preclinical research has gained further insight into the nature of HDL-C metabolism, specifically regarding the ability of HDL-C to promote reverse cholesterol transport (RCT). Recent attempts to harness HDL's ability to enhance RCT have revealed the complexity of HDL-C metabolism. This review provides a detailed update on HDL-C as an evolving therapeutic target in the management of cardiovascular disease.
- Publication
Vascular Health & Risk Management, 2008, Vol 4, Issue 1, p39
- ISSN
1176-6344
- Publication type
journal article