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- Title
Myeloid Antigen-positive T Cell Acute Lymphocytic Leukemia with t(14;18) and Trisomy 10: Report of a Case and Literature Review.
- Authors
Guoqiang Lin; Limin Liu; Guangsheng Zhao; Yejun Si; Xingxia Zhang; Yumei Sun; Shuhua Lu; Yanming Zhang
- Abstract
The chromosomal translocation t(14; 18)(q32;q21) is commonly associated with neoplasms of follicular center cell origin and has also been reported in cases of chronic lymphocytic leukemia. However, T cell acute lymphoblastic (or lymphocytic) leukemia (T-ALL) with t(14;18)(q32;q21) has been rarely reported. Here, we report a case of myeloid antigen-positive T-ALL (My+T-ALL) with t(14;18)(q32;q21) and trisomy 10. This is the first reported case of My+T-ALL (L2) with such chromosomal abnormalities. Other published cfe novo ALL cases, with t(14;18)(q32;q21) and without a documented history of lymphoma, are summarized and reviewed in this report. The patient in this study was treated with remission induction therapy and intensive chemotherapy, followed by maintenance therapy. As of this writing, he has remained in remission for more than 3 years and has presented a better clinical outcome compared with other reported adult ALL patients witht(14;18)(q32;q21).
- Publication
Archives of Iranian Medicine (AIM), 2015, Vol 18, Issue 8, p537
- ISSN
1029-2977
- Publication type
Journal Article
- DOI
015188/AIM.0011