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- Title
Synthesis, Luminescence and Relaxometric Properties of Macrocyclic Lanthanide Complexes Appended with an Imidazothiadiazole, a Heterocyclic Bioactive Scaffold.
- Authors
Ndiaye, Modou; Caillet, Emma; Eliseeva, Svetlana V.; Masson, Thibaut; Marchetti, Luke A.; Pallier, Agnès; Morfin, Jean‐François; Petoud, Stéphane; Routier, Sylvain; Buron, Frédéric; Bonnet, Célia S.
- Abstract
The syntheses of two macrocycles containing original imidazothiadiazole heterocycles are presented. The protonation constants of the ligands have been determined by potentiometry and photophysical measurements. The photophysical properties of the corresponding Tb3+ complexes have been analyzed and the sensitization of the Tb3+ by the heterocyclic moiety demonstrated with modest quantum yields. The corresponding Gd3+ complexes are monohydrated and display higher relaxivities than GdDOTA, which could be explained by the larger size of these complexes. The different substitutions on the heterocycle do not affect strongly the protonation constants of the ligand, the quantum yield, water exchange rate or relaxation properties of the system.
- Subjects
RARE earth metals; PROTONATION constants; LUMINESCENCE; FOREIGN exchange rates; MAGNETIC resonance imaging; POTENTIOMETRY
- Publication
European Journal of Inorganic Chemistry, 2024, Vol 27, Issue 7, p1
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.202300648