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- Title
Synthesis of Pyridone Derivatives from 7-Hydroxy-7-polyfluoroalkylhexahydroimidazo[1,2-a]pyridin-5-ones.
- Authors
Goryaeva, Marina V.; Burgart, Yanina V.; Kudyakova, Yulia S.; Ezhikova, Marina A.; Kodess, Mikhail I.; Saloutin, Victor I.
- Abstract
The synthesis of 1-(2-aminoethyl)-6-alkyl-4-polyfluoroalkylpyridin-2-ones based on the acidic cleavage of 7-hydroxy-7-polyfluoroalkylhexahydroimidazo[1,2-a]pyridin-5-ones is reported. Depending on the reaction conditions, the pyridones can be obtained as bases, salts, acetamides, or the products of intramolecular cyclization, dihydroimidazopyridines. High tuberculostatic activity was observed for some of the synthesized compounds.
- Subjects
PYRIDONE derivatives; PYRIDINE; HETEROCYCLIC compounds; DEHYDRATION reactions; RING formation (Chemistry); CHEMICAL synthesis
- Publication
European Journal of Organic Chemistry, 2017, Vol 2017, Issue 27, p3986
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201700683