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- Title
<sup>11</sup>C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer's disease in the absence of known mutations retains higher levels of PIB in the basal ganglia.
- Authors
Young Chul Youn; Jae-Won Jang; Su-Hyun Han; HyeRyoun Kim; Ju-Won Seok; Jun Soo Byun; Kwang-Yeol Park; An, Seong Soo A.; In Kook Chun; SangYun Kim
- Abstract
Purpose: Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent. Methods: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer's disease: 9 patients with EOAD (age, 65), 11 with LOAD (age .70) and 8 normal controls (NCs), all of whom had undergone 11C-labeled Pittsburgh compound B-positron emission tomography imaging. Results: Patients with EOAD exhibited higher z scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (P,0.05, false discovery rate). Conclusion: Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD.
- Subjects
ALZHEIMER'S disease diagnosis; GENETIC mutation; BASAL ganglia
- Publication
Clinical Interventions in Aging, 2017, Vol 12, p1041
- ISSN
1178-1998
- Publication type
Article
- DOI
10.2147/CIA.S132884