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- Title
In situ biosynthetic BC/zeolite hybrid hemostat for quick clot.
- Authors
Wang, Yang; Li, Zhuquan; Liao, Shiqin; Kong, Yan; Wang, Qingqing; Wei, Qufu
- Abstract
Zeolite‐based hemostatic agents are considered as an outstanding material to achieve rapid and definitive hemostasis in pre‐hospital management. However, developing a safer zeolitic hemostat that avoids the potential thrombotic risk caused by tiny zeolite residue in bleeding wounds remains a critical challenge. In this research, we employ an in situ biosynthesis process to fabricate a sandwich‐like structured bacterial cellulose/zeolite (BC/zeolite) hybrid hemostat. Zeolite particles were firmly bonded into the BC membranes with <1% leaching after 24 soaking. This hemostat displays effective hemostatic performance after calcium ion‐exchange process. The BC/zeolite‐Ca hemostat can significantly decrease in vitro blood clotting time from 7.5 ± 0.3 min to 2.2 ± 0.3 min. This work achieves a low‐cost, eco‐friendly, and low‐risk approach through in situ biosynthesis in the preparation of BC‐ and zeolite‐based hybrid for pre‐hospital hemostasis applications.
- Subjects
BLOOD coagulation; HEMATOLOGIC agents; ZEOLITES; ION exchange (Chemistry); HEMOSTASIS; CELLULOSE
- Publication
Journal of Applied Polymer Science, 2023, Vol 140, Issue 34, p1
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.54315