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- Title
The jury is still out on the existence of a placental microbiome.
- Authors
Briana, Despina D.; Papaevangelou, Vassiliki; Malamitsi‐Puchner, Ariadne; Malamitsi-Puchner, Ariadne
- Abstract
The human microbiome is crucial for regulating normal development, but the exact point when it is established remains unknown. A sterile placenta was traditionally considered a prerequisite for a healthy pregnancy, but studies have revealed that the placenta harbours microbial communities, even under normal conditions. However, reports have failed to provide evidence for the consistent presence of bacteria in the normal human placenta, challenging the in utero colonisation hypothesis. This mini review examines our understanding of the potential placental microbial colonisation in normal healthy pregnancies. This may impact the metabolic and immune functions of the growing foetus and have long-term consequences.
- Subjects
PLACENTA; COLONIZATION (Ecology); HUMAN microbiota; MICROBIAL communities; FETUS; INFERTILITY; BACTERIA
- Publication
Acta Paediatrica, 2021, Vol 110, Issue 11, p2958
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.16048