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- Title
Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study.
- Authors
Duan, Chuanxin; Zhou, Wangji; Zhang, Miaoyan; Cheng, Chongsheng; Xu, Wenshuai; Dai, Jinrong; Meng, Shuzhen; Chen, Keqi; Zhao, Yang; Liu, Song; Wang, Shao-Ting; Yang, Yanli; Xu, Kai-Feng; Tian, Xinlun
- Abstract
Background: Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare interstitial lung disease. COVID-19 is associated with worse prognosis in previous lung diseases patients. But the prognosis of aPAP patients after infection with COVID-19 is unclear. In December 2022, China experienced a large-scale outbreak of Omicron variant of the SARS-CoV-2. In this study, we aim to explore the clinical outcomes of aPAP patients infected with COVID-19. Results: A total of 39 aPAP patients were included in this study. 30.77% patients had a decrease in oxygen saturation after COVID-19 infection. We compared the two groups of patients with or without decreased oxygen saturation after COVID-19 infection and found that patients who had previous oxygen therapy (decreased oxygen saturation vs. non decreased oxygen saturation: 6/12 vs. 4/27, P = 0.043), with lower baseline arterial oxygen partial pressure (74.50 ± 13.61 mmHg vs. 86.49 ± 11.92 mmHg, P = 0.009), lower baseline DLCO/VA% [77.0 (74.3, 93.6) % vs. 89.5 (78.2, 97.4) %, P = 0.036], shorter baseline 6MWD [464 (406, 538) m vs. 532 (470, 575) m, P = 0.028], higher disease severity score (P = 0.017), were more likely to have decreased oxygen saturation after COVID-19 infection. Conclusion: aPAP patients with poor baseline respiration have a higher probability of hypoxia after COVID-19 infection, but fatal events were rare.
- Subjects
PULMONARY alveolar proteinosis; SARS-CoV-2 Omicron variant; COVID-19; INTERSTITIAL lung diseases; OXYGEN saturation
- Publication
Orphanet Journal of Rare Diseases, 2023, Vol 18, Issue 1, p1
- ISSN
1750-1172
- Publication type
Article
- DOI
10.1186/s13023-023-02950-9