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- Title
Predicting the conformations of peptides and proteins in early evolution. A review article submitted to Biology Direct.
- Authors
Milner-White, E. James; Russell, Michael J.
- Abstract
Considering that short, mainly heterochiral, polypeptides with a high glycine content are expected to have played a prominent role in evolution at the earliest stage of life before nucleic acids were available, we review recent knowledge about polypeptide three-dimensional structure to predict the types of conformations they would have adopted. The possible existence of such structures at this time leads to a consideration of their functional significance, and the consequences for the course of evolution. This article was reviewed by Bill Martin, Eugene Koonin and Nick Grishin.
- Subjects
PROTEIN conformation; PEPTIDES; BIOLOGICAL evolution; MORPHOLOGY; POLYPEPTIDES
- Publication
Biology Direct, 2008, Vol 3, p1
- ISSN
1745-6150
- Publication type
Article
- DOI
10.1186/1745-6150-3-3