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- Title
Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link.
- Authors
Sachak, Taha; Heerema, Nyla A.; Mayerson, Joel; Payne, Jason E.; Parwani, Anil; Iwenofu, O. Hans
- Abstract
Background: Ischemic fasciitis is a distinctive pseudosarcomatous entity with a marked predilection for elderly and physically debilitated or immobilized patients. The etiology of these lesions is unknown but felt to be related to ischemic vascular events. Case presentation: Herein, we report for the first time, two cytogenetic translocations, t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) in a 75 year-old ambulating female with a history of left total hip arthroplasty 20 years ago. Conclusion: These translocations suggest a possible clonal pathogenetic link though their significance remains to be established.
- Subjects
CHROMOSOMAL translocation; NODULAR fasciitis; OLDER patients; CYTOGENETICS; TOTAL hip replacement; PATIENTS
- Publication
Diagnostic Pathology, 2018, Vol 13, p1
- ISSN
1746-1596
- Publication type
Article
- DOI
10.1186/s13000-018-0695-y