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- Title
Análise Morfológica da Mucosa Oral de Ratos Submetida à Carcinogênese Experimental pelo Óxido de Nitroquinolina (4NQO).
- Authors
Henriques, Aguida Cristi Na Gomes; Cazal, Cláudia; Lins, Rafael Claudino; De Castro, Jurema Freire Lisboa
- Abstract
Objective: To induce carcinogenesis on the lingual mucosa of Wistar rats by the administration of nitroquinoline oxide (4NQO), relati ng the clinical and microscopic alterations developed during the ti me of exposure to the carcinogenic agent. Methods: Twenty rats were allocated to either an experimental (15 animals) or a control (5 animals) group. In the experimental group, the animals were divided into 3 subgroups in which 5 animals received 4NQO during 2 months (A1), 5 during 3 months (A2), and 5 during 4 months (A3), making it possible to detect the different phases of carcinogenesis. Data were presented as descriptive statistics using the Kruskal-Wallis and Mann-Whitney tests in the SPSS (Statistical Package for the Social Sciences) soft ware, version 13.0. The significance level was set at 5.0%. Results: Both the animal model and the carcinogenic agent used in the study were sati sfactory for inducing similar oral carcinogenesis to the one occurring in humans. The clinical alterations were more accentuated in the animals that received the topical applications of 4NQO during 4 months, ranging from leukoplakia to erythroleukoplakias regions. The histopathological alterations observed in the oral epithelium were compati ble with the diagnosis of mild, moderate and severe epithelial dysplasia, in situ carcinoma or invasive carcinoma. Conclusion: The severity of the lesions had a direct relationship with the exposure ti me to 4NQO.
- Subjects
ORAL mucosa; LABORATORY rats; CHEMISTRY experiments; CARCINOGENESIS; NITROQUINOLINE oxide; CARCINOMA in situ; SQUAMOUS cell carcinoma
- Publication
Pesquisa Brasileira em Odontopediatria e Clinica Integrada, 2011, Vol 11, Issue 1, p13
- ISSN
1519-0501
- Publication type
Article
- DOI
10.4034/PBOCI.2011.111.02