We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Many Bacterial Species are Mitogenic for Human Blood B Lymphocytes.
- Authors
Banck, G.; Forsgren, A.
- Abstract
Thirty bacterial species were tested for their ability to stimulate to increased DNA synthesis in human blood lymphocytes. A definite stimulation was obtained with eighteen bacterial species. For three of these species ten different strains of each were tested, and all increased DNA synthesis. The maximum response was after 3-4 days of culture, suggesting a mitogenic effect. This was confirmed by the induction of polyclonal antibody production shown by a plaque assay, which was positive for nine of eleven species tested. Most bacterial species increased the DNA synthesis in B-lymphocyte-enriched and unseparated lymphocytes bus had negligible activity on T-lymphocyte-enriched cultures. Among bacteria with a mitogenic effect and ability to induce polyclonal antibody production are Staphylococcus aureus strain Cowan 1 with a high content of protein A and many common human pathogens such as Haemophilus influenzae, Mycobacterium tuberculosis, Neisseria gonorrhoeae, Streptococcus group A and Streptococcus pneumoniae.
- Subjects
LYMPHOCYTES; DNA synthesis; B cells; T cells; IMMUNOGLOBULINS; BACTERIAL diseases
- Publication
Scandinavian Journal of Immunology, 1978, Vol 8, Issue 4, p347
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1978.tb00528.x