We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of Fch and Fc Fragments of IgG3: Evidence of an Intra-Chain S--S Bridge in the Hinge of γ3 Chains.
- Authors
Michaelsen, T. E.; Natvig, J. B.
- Abstract
The Fc and Fch fragments of human IgG3, appearing late and early during papain digestion, respectively, were antigenically and structurally compared. Only the Fch fragment reacted with an anti-Fh (hinge region-specific) antiserum; thus the main portion of the hinge region is split off during the formation of Fc fragments. The Fch fragment has a higher content of inter-chain S--S bridges than the Fc fragments. The Fc fragments are probably a mixture of there related fragments. The Fch fragment appears to be more homogeneous, although there was hydrolysis at the C-terminal site of the hinge region in some of the Fch chains. Evidence is presented that the γ3 chain bridge has an extra intra-heavy-chain disulphide bridge at the C-terminal end of the hinge region.
- Subjects
CYSTEINE proteinases; HYDROLYSIS; VIADUCTS; PROTEINASES; BROMELIN; NUTRITION
- Publication
Scandinavian Journal of Immunology, 1974, Vol 3, Issue 6, p865
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1974.tb01325.x