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- Title
Influence of tuberculosis on human immunodeficiency virus (HIV-1): enhanced cytokine expression and elevated beta 2-microglobulin in HIV-1-associated tuberculosis.
- Authors
Wallis, Robert S.; Vjecha, Michael; Amir-Tahmasseb, Manijeh; Okwera, Alphonse; Byekwaso, Fred; Nyole, Sam; Kabengera, Sam; Mugerwa, Roy D.; Ellner, Jerrold J.; Wallis, R S; Vjecha, M; Amir-Tahmasseb, M; Okwera, A; Byekwaso, F; Nyole, S; Kabengera, S; Mugerwa, R D; Ellner, J J
- Abstract
Tuberculosis results in activation of T cells and macrophages that may harbor latent human immunodeficiency virus (HIV-1), Although such activation is beneficial to the host in terms of mycobacterial disease, it may be deleterious in terms of HIV-1. In Ugandan HIV-.-seropositive patients with pulmonary tuberculosis, antigen-induced blastogenesis and production of tumor necrosis factor-α (a cytokine that induces expression of HIV-1 in latently infected cells) were 3–10 times greater than in controls. The mean serum β2-microglobulin level was 5.22 mg/L in recently diagnosed patients, significantly greater than levels in HIV-negative patients with tuberculosis or asymptomatic HIV-1-seropositive subjects. β2-microglobulin was significantly lower in subjects who had completed at least 2 months of antituberculous therapy. These observations suggest that HIV-1-associated tuberculosis is accompanied by immune activation that may result in increased HIV expression and accelerated progression to AIDS.
- Publication
Journal of Infectious Diseases, 1993, Vol 167, Issue 1, p43
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/167.1.43