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- Title
Long-term follow-up of dose-adjusted EPOCH plus rituximab (DA-EPOCH-R) in untreated patients with poor prognosis large B-cell lymphoma. A phase II study conducted by the Spanish PETHEMA Group.
- Authors
Purroy, Noelia; Bergua, Juan; Gallur, Laura; Prieto, Julio; Lopez, Luis A.; Sancho, Juan M.; García‐Marco, Jose A.; Castellví, Josep; Montes‐Moreno, Santiago; Batlle, Ana; Villambrosia, Sonia Gonzalez; Carnicero, Fernando; Ferrando‐Lamana, Lucía; Piris, Miguel A; Lopez, Andrés
- Abstract
This prospective multi-institutional phase II study was designed to assess the efficacy and safety of dose-adjusted EPOCH (etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin) plus rituximab ( DA-EPOCH-R) in untreated patients with poor prognosis large B-cell lymphomas. Eighty-one patients diagnosed with diffuse large B-cell lymphoma ( DLBCL, n = 68), primary mediastinal DLBCL ( n = 6) and follicular lymphoma Grade 3b ( n = 7), with an age-adjusted International Prognostic Index >1, were eligible for analysis. Median age was 60 years (range: 21-77). Sixty-five patients (80·2%) achieved complete response. After a median follow-up time of 64 months, 10-year event-free survival and overall survival ( OS) were 47·8% and 63·6%, respectively. None of the studied clinical and biological characteristics were associated with poorer outcome. Interestingly, patients with BCL6 rearrangement achieved a 10-year OS of 100%, while patients with BCL2 rearrangement exhibited a poorer outcome compared to activated B-cell tumours and germinal centre B-cell without BCL2 rearranged tumours. Results achieved with DA-EPOCH-R showed a good long-term outcome and a tolerable toxicity profile in high-risk large B cell lymphoma patients. Outcome was not affected by tumour cell proliferation or by cell of origin, highlighting the requirement of new biological markers for patient subclassification of high-risk DLBCL patients.
- Subjects
B cell lymphoma; RITUXIMAB; MEDICATION safety; DRUG efficacy; FOLLOW-up studies (Medicine); PATIENTS; PROGNOSIS
- Publication
British Journal of Haematology, 2015, Vol 169, Issue 2, p188
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.13273