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- Title
Very high frequencies of leukaemia-initiating cells in precursor T-acute lymphoblastic leukaemia may be obscured by cryopreservation.
- Authors
Greystoke, Brigit F.; Huang, Xu; Wilks, Deepti P.; Atkinson, Shayne; Somervaille, Tim C. P.
- Abstract
The article focuses on a study on the cryopreservation of primary human precursor T-acute lymphoblastic leukaemia (ALL) cells through the use of standard techniques. It states the application of xenotransplantation in determining and characterizing human acute leukaemia cells that have leukemia-initiating stem cell (LSC) potential. Result shows that the transplantation of 10 fresh T-ALL cells led to robust xenoengraftment in each of three recipients.
- Subjects
CRYOPRESERVATION of organs, tissues, etc.; LYMPHOBLASTIC leukemia; T cells; XENOGRAFTS; STEM cells
- Publication
British Journal of Haematology, 2013, Vol 163, Issue 4, p538
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.12511