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- Title
Interactions between physical activity and variants of the genes encoding uncoupling proteins -2 and -3 in relation to body weight changes during a 10-y follow-up.
- Authors
Berentzen, T.; Dalgaard, L.T.; Petersen, L.; Pedersen, O.; Sørensen, T.I.A.; Sørensen, T I A
- Abstract
<bold>Objective: </bold>To examine interactions between physical activity and possibly functional variants of the genes encoding uncoupling proteins -2 and -3 in relation to body weight change. We hypothesize that physical inactivity acts synergistically with a 45 bp insertion variant in the 3'untranslated region (3'UTR) of the UCP2-gene and with a t-allele of codon -55 in the promoter of the UCP3-gene in relation to subsequent weight change. <bold>Design: </bold>Population-based longitudinal study of cohorts of juvenile obese and nonobese men, who were identified at the mandatory draft board examination in Copenhagen and adjacent regions at a median age of 19 y in 1943-77 and later examined at general health surveys in 1981-83 and 1991-93. The juvenile obese cohort included 568 men who at the draft board had a BMI > or =31 kg/m2 and the cohort of controls included 717 randomly selected draftees. <bold>Measurements: </bold>Height and weight were measured, and information about physical activity was collected from a self-administered questionnaire. The genotyping of the polymorphisms was performed using RFLP techniques. The main outcome measure was change in BMI during the 10-y follow-up period. Additional outcome measures were obesity, waist circumference and body fat mass index measured at follow-up. <bold>Results: </bold>Physical activity, the 3'UTR insertion polymorphism and the -55 c/t polymorphism were not consistently associated with changes in BMI, and there were no evidence for interactions between the UCP-variants and physical activity in relation to changes in BMI. No evidence for interaction between the UCP-variants and physical activity was found in relation to the additional obesity measures. <bold>Conclusion: </bold>This study does not support that interactions between physical activity and variants in the UCP2- or UCP3-gene are major determinants of subsequent weight changes in Danish Caucasian men.
- Subjects
PHYSICAL fitness; BODY weight; OBESITY; OVERWEIGHT persons; METABOLIC disorders; CARRIER proteins; COMPARATIVE studies; GENES; GENETIC polymorphisms; LEISURE; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; MEMBRANE proteins; MOTOR ability; PROTEINS; RESEARCH; RNA; EVALUATION research; BODY mass index; CASE-control method; MEMBRANE transport proteins
- Publication
International Journal of Obesity, 2005, Vol 29, Issue 1, p93
- ISSN
0307-0565
- Publication type
journal article
- DOI
10.1038/sj.ijo.0802841