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- Title
The Molecular of human „cochlear battery” - Aspects on hearing preservation CI surgery.
- Authors
Liu, W.; Li, H.; Schrott-Fischer, A.; Glueckert, R.; Garnham, C.; Benav, H.; Helge Rask-Andersen H.
- Abstract
Objectives: Atraumatic CI-surgery is a requisite for preservation of residual hearing, also at long term. Round window electrode insertion seems more atraumatic but the anatomy can vary surprisingly and this can challenge preservation of the soft tissue. Further understanding of human cochlear physiology is necessary to understand the impact of different electrode trajectories. Material and Methods: We analysed the molecular constituents the human, so-called "cochlear battery" or generator of the endo-cochlear potential in the lateral wall essential for hair cell function/transduction. We used fluorescence immunohistochemistry, including super-resolution structured illumination microscopy (SR-SIM), of the human cochlear tissue at Uppsala SciLife national facilities (http://www.scilifelab.se/#). A lateral precision of approximately 80 nm and 250 nm axially were obtained. Results and Conclusions: The battery isolator was disclosed as specialized cells expressing protein Claudin-11. It forms a "wall" around the ion channel and transporter cells. A breach of this barrier, such as caused by CI insertion trauma, may cause loss of residual hearing and deafness. The unique and separate distribution of homomeric connexin26/30 isoforms was demonstrated. The significance of the findings related to hearing preservation CI surgery is discussed
- Subjects
BELGIUM; CONFERENCES &; conventions; AUDITORY perception; COCHLEAR implants; INNER ear
- Publication
Journal of Hearing Science, 2018, Vol 8, Issue 2, p274
- ISSN
2083-389X
- Publication type
Article