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- Title
Human vascular adhesion protein-1 (VAP-1): Serum levels for hepatocellular carcinoma in non-alcoholic and alcoholic fatty liver disease.
- Authors
Kemik, Ozgur; Sümer, Aziz; Kemik, Ahu Sarbay; Itik, Veyis; Dulger, Ahmet Cumhur; Purisa, Sevim; Tuzun, Sefa
- Abstract
Background: The incidence of hepatocellular cancer in complicated alcoholic and non-alcoholic fatty liver diseases is on the rise in western countries as well in our country. Vascular adhesion protein-1 (VAP-1) levels have been presented as new marker. In our study protocol, we assessed the value of this serum protein, as a newly postulant biomarker for hepatocellular cancer in patients with a history of alcoholic and non-alcoholic fatty liver diseases. Methods: Pre-operative serum samples from 55 patients with hepatocellular cancer with a history of alcoholic and non-alcoholic fatty liver diseases and patients with cirrhosis were assessed by a quantitative sandwich ELISA using anti-VAP-1 mAbs. This technique is used to determine the levels of soluble VAP-1 (sVAP-1) in the serum. Results: sVAP-1 levels were evaluated in patients with hepatocellular cancer and liver cirrhosis. There was a significant difference in mean VAP-1 levels between groups. Serum VAP-1 levels were found higher in patients with hepatocellular cancer. Conclusion: These findings indicate that the serum level of sVAP-1 might be a beneficial marker of disease activity in chronic liver diseases.
- Subjects
LIVER cancer; FATTY liver; PROTEINS; SERUM; BIOMARKERS; CIRRHOSIS of the liver; PATIENTS; ALCOHOLS (Chemical class); WESTERN countries
- Publication
World Journal of Surgical Oncology, 2010, Vol 8, p83
- ISSN
1477-7819
- Publication type
Article
- DOI
10.1186/1477-7819-8-83