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- Title
A Great Barrier Reef Sinularia sp. Yields Two New Cytotoxic Diterpenes.
- Authors
Wright, Anthony D.; Nielson, Jonathan L.; Tapiolas, Dianne M.; Liptrot, Catherine H.; Motti, Cherie A.
- Abstract
The methanol extract of a Sinularia sp., collected from Bowden Reef, Queensland, Australia, yielded ten natural products. These included the new nitrogenous diterpene (4R*,5R*,9S*,10R*,11Z)-4-methoxy-9-((dimethylamino)-methyl)-12,15-epoxy-11 (13)-en-decahydronaphthalen-16-ol (1), and the new lobane, (1R*,2R*,4S*,15E)-loba-8,10, 13(14),15(16)-tetraen-17,18-diol-17-acetate (2). Also isolated were two known cembranes, sarcophytol-B and (1E,3E,7E)-11,12-epoxycembratrien-15-ol, and six known lobanes, loba-8, 10,13(15)-triene-16,17,18-triol, 14,18-epoxyloba-8,10,13(15)-trien-17-ol, lobatrientriol, lobatrienolide, 14,17-epoxyloba-8,10,13(15)-trien-18-ol-18-acetate and (17R)-loba-8,10,13 (15)-trien-17,18-diol. Structures of the new compounds were elucidated through interpretation of spectra obtained after extensive NMR and MS investigations and comparison with literature values. The tumour cell growth inhibition potential of 1 and 2 along with loba-8,10,13(15)-triene-16,17,18-triol, 14,17-epoxyloba-8,10,13 (15)-trien-18-ol-18-acetate, lobatrienolide, (1E,3E,7E)-11,12-epoxycembratrien-15-ol and sarcophytol-B were assessed against three human tumour cell lines (SF-268, MCF-7 and H460). The lobanes and cembranes tested demonstrated 50% growth inhibition in the range 6.8-18.5 &mgr;M, with no selectivity, whilst 1 was less active (GI50 70-175 &mgr;M).
- Subjects
GREAT Barrier Reef; QUEENSLAND; AUSTRALIA; DITERPENES; ANTINEOPLASTIC agents; METHANOL; NATURAL products; CORALS
- Publication
Marine Drugs, 2012, Vol 10, Issue 8, p1619
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md10081619