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- Title
Uroguanylin induces electroencephalographic spikes in rats.
- Authors
Teixeira, M. D. A.; Nascimento, N. R. F.; Fonteles, M. C.; Vale, O. C.
- Abstract
Uroguanylin (UGN) is an endogenous peptide that acts on membrane-bound guanylate cyclase receptors of intestinal and renal cells increasing cGMP production and regulating electrolyte and water epithelial transport. Recent research works demonstrate the expression of this peptide and its receptor in the central nervous system. The current work was undertaken in order to evaluate modifications of electroencephalographic spectra (EEG) in anesthetized Wistar rats, submitted to intracisternal infusion of uroguanylin (0.0125 nmoles/min or 0.04 nmoles/min). The current observations demonstrate that 0.0125 nmoles/min and 0.04 nmoles/min intracisternal infusion of UGN significantly enhances am-plitude and frequency of sharp waves and evoked spikes (p = 0.03). No statistical significance was observed on abso-lute alpha and theta spectra amplitude. The present data suggest that UGN acts on bioelectrogenesis of cortical cells by inducing hypersynchronic firing of neurons. This effect is blocked by nedocromil, suggesting that UGN acts by in-creasing the activity of chloride channels.
- Subjects
UROGUANYLIN; ELECTROENCEPHALOGRAPHY; LABORATORY rats; GUANYLATE cyclase; CYCLIC guanylic acid; EPITHELIAL cells; PEPTIDE receptors
- Publication
Brazilian Journal of Biology, 2013, Vol 73, Issue 3, p623
- ISSN
1519-6984
- Publication type
Article
- DOI
10.1590/S1519-69842013000300021