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- Title
Effect of pre-operative internal obturator muscle mass index in MRI on biochemical recurrence of prostate cancer patients after radical prostatectomy: a multi-center study.
- Authors
Kim, Won Tae; Kang, Ho Won; Seo, Sung Pil; Kim, Yong-June; Lee, Sang Cheol; Kim, Wun-Jae; Cho, Bum Sang; Ha, Yun Sok; Kwon, Tae Gyun; Park, Jinsung; Park, Seung Chol; Jeong, Young Beom; Kang, Taek Won; Park, Sung-Woo; Yun, Seok Joong
- Abstract
<bold>Background: </bold>Recent reports show that the pre-operative or post-operative skeletal mass index (sarcopenia) affects survival rates for various cancers; however, the link between prostate cancer survival and sarcopenia is unclear. Therefore, this study examined the effect of the pre-operative internal obturator muscle (IOM) mass index on biochemical recurrence (BCR) of prostate cancer (PCa) patients who underwent radical prostatectomy.<bold>Methods: </bold>In total, 222 patients, who underwent open, laparoscopic, or robot-assisted radical prostatectomy at seven centers in 2011 and were followed up for 5 years, were enrolled. BCR was examined in the context of pre-operative IOM mass index and BMI.<bold>Results: </bold>The mean age of the patients was 67.82 ± 6.23 years, and the mean pre-operative prostate-specific antigen (PSA) level was 11.61 ± 13.22 ng/ml. There was no significant difference in baseline characteristics between the low and high IOM mass index groups (p > 0.05). Age, pre-op PSA level, ECE, and T-stage were associated with BCR (p = 0.049, p < 0.001, p = 0.001, p = 0.004, respectively). BMI, prostate volume, Gleason score, resection margin, N-stage, M-stage and IOM mass index was not associated with BCR (p > 0.05).<bold>Conclusions: </bold>Pre-operative IOM mass index was not associated with BCR; however, long-term follow-up is necessary to evaluate cancer-specific and overall survival of PCa patients.
- Subjects
INTERNATIONAL Organization for Migration; PROSTATECTOMY; RADICAL prostatectomy; PROSTATE cancer patients; MUSCLE mass; CANCER relapse; SURGICAL margin
- Publication
BMC Urology, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2490
- Publication type
journal article
- DOI
10.1186/s12894-021-00853-0