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- Title
A new landscape for malaria vaccine development.
- Authors
Laurenson, Alexander J.; Laurens, Matthew B.
- Abstract
The World Health Organization (WHO) has recommended two vaccines for malaria prevention, but neither vaccine meets the desired efficacy and durability for an optimal malaria vaccine. However, there are multiple next-generation vaccines in clinical testing that aim to provide higher efficacy, decrease vaccine delivery demands, and improve cost effectiveness. Computational biology plays a crucial role in informing the design of these vaccines, with techniques such as mRNA-lipid nanoparticle technology offering advantages such as quick manufacturing and safety for infants and pregnant women. The article also discusses the strategy of combining existing vaccines with additional antigens to improve efficacy and the potential of transmission-blocking vaccines. Overall, next-generation vaccines are seen as crucial in achieving malaria elimination goals and improving child health in endemic areas.
- Subjects
MALARIA vaccines; OOCYSTS; VACCINE development; VACCINATION; MALARIA prevention
- Publication
PLoS Pathogens, 2024, Vol 20, Issue 6, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1012309