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- Title
Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression.
- Authors
Zhu, Jing-Jie; Huang, Jun-Shang; Wang, Ting; Ji, Jun; Hou, Ai-Jun; Wang, He-Yao
- Abstract
Adipose tissue is not only a lipid storage site, but also a well-known endocrine organ. Dysfunction of adipose tissue is associated with irregular lipid metabolism, ectopic lipid accumulation and insulin resistance. It is proposed that modulating on adipose tissue is a reasonable way to ameliorate glucose and lipid metabolism. (±)-sanggenol F (SGF, purity >98.5%) was synthesized as a racemic mixture of natural (+)-sanggenol F. In this study, SGF was found to promote adipocyte differentiation, enhance insulin sensitivity, and upregulate beneficial adipokines expression in 3T3-L1 cells. Furthermore, in vivo study showed that treatment with SGF for 4 weeks improved glucose metabolism, by decreasing fasting blood glucose and enhancing insulin sensitivity. It also improved lipid metabolism, with reduced serum lipid level and ameliorated hepatic steatosis in db/db mice. During the process of target finding, we found that SGF had multiple activities of protein tyrosine phosphatase 1B inhibition, peroxisome proliferator-activated receptor γ and peroxisome proliferator-activated receptor α agonism. These results showed the potential of SGF as a candidate for the therapy of type 2 diabetes.
- Publication
Endocrine (1355008X), 2017, Vol 56, Issue 1, p73
- ISSN
1355-008X
- Publication type
Article
- DOI
10.1007/s12020-016-1203-3