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- Title
Preliminary Study of Honey Hydrogel Dressing for Burn Wound Healing in Rat Model.
- Authors
M. Z., Rozaini; N., Yusof; A. B., Zuki; H., Asnah
- Abstract
BACKGROUND The objective of this study was to develop and evaluate honey hydrogel dressing for wound healing application. MATERIALS AND METHOD To enhance further the use of our local honey in wound treatment and for easy handling, Gelam honey was incorporated into our hydrogel dressing formulation which was then cross-linked and sterilized using electron beam irradiation (25 kGy). Study was carried out on the physical properties of the hydrogel and diffusion rate of the honey from the hydrogel. The healing properties of honey hydrogel dressing on burn wound healing were investigated using 18 Sprague- Dawley male rats weighing 200-300 g. Deep partial skin thickness burns were inflicted on the dorsal part of each animal. The progress of wound healing was observed at 7, 14 and 21 days post burn. Rats were euthanized at 21 day post burn and skin samples collected were subjected to histological study. RESULTS Release study of honey hydrogel showed sustained release of honey for up to 7 days. In vivo healing study showed that there was a significant acceleration of the dermal repair in wound healing treated with honey hydrogel dressing compared to control group. Early attenuation of inflammatory reaction and early reparative activities were observed in wounds treated with honey hydrogel dressing. In addition, epithelial regeneration appeared to be significant in honey hydrogel treated wound. CONCLUSION The results of this study suggested that honey hydrogel wound dressing has the potential to modulate wound healing compared to hydrogel alone.
- Subjects
HONEY; HYDROGELS; WOUND healing; LABORATORY rats; WOUND care
- Publication
Malaysian Journal of Medical Sciences, 2007, Vol 14, Issue 1, p112
- ISSN
1394-195X
- Publication type
Article