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- Title
Structural insights into ligand binding and gene expression control by an adenosylcobalamin riboswitch.
- Authors
Peselis, Alla; Serganov, Alexander
- Abstract
Coenzyme B12 has a key role in various enzymatic reactions and controls expression of bacterial genes through riboswitches. Here we report the crystal structure of the Symbiobacterium thermophilum B12 riboswitch bound to its ligand adenosylcobalamin. The riboswitch forms a unique junctional structure with a large ligand-binding pocket tailored for specific recognition of the adenosyl moiety and flanked by structural elements that stabilize the regulatory region and enable control of gene expression.
- Subjects
MESSENGER RNA; GENE expression; RIBOSWITCHES; LIGAND binding (Biochemistry); VITAMIN synthesis; COENZYMES
- Publication
Nature Structural & Molecular Biology, 2012, Vol 19, Issue 11, p1182
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2405