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- Title
RNA Interference to Suppress Flaviviral Encephalitis.
- Abstract
The article focusses on the treatment of multiple viruses including Japanese encephalitis virus (JEV) and West Nile virus (WNV) caused by mosquito bite. Clinical trials on mice on the possibility of RNA interference (RNAi)-based intervention in suppressing lethal JEV and WNV encephalitis. Proofs that specific siRNA used intranasally could prevent single and concurrent infections in mice. Inhaled siRNA being a promosing strategy for anti-RSV and anti-PIV therapy in humans is discussed.
- Subjects
JAPANESE B encephalitis; TREATMENT of West Nile fever; SMALL interfering RNA; LABORATORY mice; RESPIRATORY syncytial virus infections; SENDAI virus; THERAPEUTICS; PREVENTION
- Publication
PLoS Medicine, 2006, Vol 3, Issue 4, pe139
- ISSN
1549-1277
- Publication type
Article
- DOI
10.1371/journal.pmed.0030139