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- Title
Inhibition by toxic compounds in the hemicellulosic hydrolysates on the activity of xylose reductase from Candida tropicalis.
- Authors
Rafiqul, I.; Sakinah, A.; Zularisam, A.
- Abstract
Xylose reductase (XR) is an oxidoreductase having potential applications in the production of various specialty products, mainly xylitol. It is important to screen for compounds that can decrease XR activity and consequently can decrease xylitol production. We have identified the byproducts in the hemicellulosic hydrolysate that inhibit XR from Candida tropicalis and measured their effects. XR inhibitory activities of byproducts, glucose, acetic acid, arabinose, lignin-degradation products (LDPs), furfural and hydroxymethylfurfural (HMF), were evaluated by measuring the MIC and IC values. XR activity was 11.2 U/ml. Acetic acid, LDPs, furfural and HMF significantly inhibited XR with IC values of 11, 6.4, 2.3 and 0.4 g/l, respectively. This is the first report on the inhibitory activities of several byproducts for XR.
- Subjects
CANDIDA tropicalis; XYLOSE reductase; HYDROLYSIS; TOXICOLOGY; XYLITOL; ACETIC acid; HYDROXYMETHYLFURFURAL; ENZYME inhibitors
- Publication
Biotechnology Letters, 2015, Vol 37, Issue 1, p191
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-014-1672-5