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- Title
Single‐cell RNA sequencing Reveals the Spatial Heterogeneity in BTKi‐Resistant proliferative drive CLL patients.
- Authors
Sha, Y.; Qin, S.; Miao, Y.; Xia, Y.; Lu, X.; Dai, L.; Qiu, T.; Wu, W.; Fan, L.; Xu, W.; Jin, H.; Li, J.; Zhu, H.
- Abstract
High proliferative tumor cells enriched in LNs showed downregulation of MHC class I and strengthened crosstalk with T cells, contributing to T cell exhaustion through activation of CD70-CD27 and LGALS9-HAVCR2. Single-cell RNA sequencing Reveals the Spatial Heterogeneity in BTKi-Resistant proliferative drive CLL patients B Introduction: b The underlying mechanisms of proliferative drive (PD) CLL including transformation of CLL to aggressive B-cell lymphoma (Richter transformation, RT) and accelerated CLL (aCLL) has not been fully disclosed yet, especially progressing after BTK inhibitor (BTKi).
- Subjects
CHRONIC lymphocytic leukemia; RNA sequencing; RICHTER syndrome; T-cell exhaustion; HETEROGENEITY
- Publication
Hematological Oncology, 2023, Vol 41, p265
- ISSN
0278-0232
- Publication type
Article
- DOI
10.1002/hon.3164_178