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- Title
CT perfusion with increased temporal sampling interval to predict target mismatch status in patients with acute ischemic stroke.
- Authors
Ma, Gao; Cao, Yue-Zhou; Shen, Guang-Chen; Lu, Shan-Shan; Zhang, Ya-Xi; Zhang, Yu; Shi, Hai-Bin; Xu, Xiao-Quan; Wu, Fei-Yun
- Abstract
Purpose: To evaluate the feasibility of using CT perfusion (CTP) with increased temporal sampling interval to predict the target mismatch status in acute ischemic stroke (AIS) patients with anterior circular large-vessel occlusion (LVO). Methods: CTP with a sampling interval of 1.7 s (CTP1.7 s) was scanned in 77 AIS patients for pre-treatment evaluation. Simulated CTP data with sampling interval of 3.4 s (CTP3.4 s) or 5.1 s (CTP5.1 s) were reconstructed, respectively. Target mismatch was defined according to the EXTEND-IA (Extending the Time for Thrombolysis in Emergency Neurological Deficits—Intra-Arterial) and DEFUSE 3 (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke) trial criteria, respectively. Pearson correlation analysis, Mann–Whitney U test, Bland–Altman analysis, and chi-square test were used for statistical analysis as appropriate. Results: Significant correlations were found on the volume of ischemic core, hypo-perfused area, mismatch area, and ratio between CTP1.7 s and CTP3.4 s or CTP5.1 s (all p < 0.001). There was no significant difference on the volume of ischemic core, hypo-perfused area, mismatch area, and mismatch ratio between CTP1.7 s and CTP3.4 s or CTP5.1 s (all p > 0.05). Compared with CTP1.7 s, CTP3.4 s or CTP5.1 s showed comparable performance in predicting the target mismatch status in the AIS patients with LVO (both p > 0.05). Conclusions: CTPs with increased temporal sampling intervals that lead to reduced radiation doses are feasible and may provide comparable performance in predicting target mismatch status in AIS patients with LVO.
- Subjects
ISCHEMIC stroke; MANN Whitney U Test; PEARSON correlation (Statistics); CHI-squared test; DESCRIPTIVE statistics; RESEARCH funding; COMPUTED tomography; PERFUSION imaging; PERFUSION; CEREBRAL ischemia; MEDICAL needs assessment
- Publication
Neuroradiology, 2023, Vol 65, Issue 1, p105
- ISSN
0028-3940
- Publication type
Article
- DOI
10.1007/s00234-022-03026-4