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- Title
Direct Conversion of 3-(2-Nitroethyl)-1 H -Indoles into 2-(1 H -Indol-2-yl)Acetonitriles.
- Authors
Aksenov, Alexander V.; Aksenov, Nicolai A.; Aleksandrova, Elena V.; Aksenov, Dmitrii A.; Grishin, Igor Yu.; Sorokina, Elena A.; Wenger, Allison; Rubin, Michael
- Abstract
The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein, we offer a workaround this problem that allows for effective transformation of the unwanted byproducts into acetonitrile target molecules.
- Subjects
ACETONITRILE; WASTE products; INDOLE compounds; NITROALKANES; MOLECULES; NITROALKENES
- Publication
Molecules, 2021, Vol 26, Issue 20, p6132
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26206132