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- Title
The effect of omega-3 fatty-acid supplements on perioperative bleeding following posterior spinal arthrodesis.
- Authors
Meredith, Dennis; Kepler, Christopher; Hirsch, Brandon; Nguyen, Joseph; Farmer, James; Girardi, Federico; O'Leary, Patrick; Cammisa, Frank
- Abstract
Purpose: To investigate the effect of omega-3 fatty-acid supplements (n-3FA) on bleeding during posterior spinal arthrodesis. Methods: We reviewed all one- or two-level posterolateral lumbar decompression/fusions with or without interbody fusion by five surgeons within 3 years. Patients taking n-3FA preoperatively were matched 1:2 with controls based on procedure, surgeon and operative time. Patients with abnormal coagulation parameters, known bleeding disorders or other medications that could affect surgical blood loss were excluded. Results: Twenty-eight patients met inclusion criteria. The n-3FA and control groups were similar with respect to gender, age, body mass index, operative time, and preoperative use of non-steroidal anti-inflammatory drugs. The n-3FAs were stopped an average of 5.2 days before surgery (range 1-10). Mean estimated blood loss (EBL) was 697 ml in the n-3FA group and 771 ml in the control group ( p = 0.36). Mean transfused volume of Cell Saver (CS) was 282 ml in the n-3FA group and 321 ml in the control group ( p = 0.30). A post hoc power analysis showed that the study was powered to detect a minimum difference of 105 ml for EBL and 50 ml for CS. The multivariate generalized estimating equation did not show a significant difference between groups for EBL or CS ( p = 0.35 and p = 0.29, respectively). Secondary outcomes including drop in postoperative hemoglobin, transfusion requirement, complications and surgical drain output were similar between the two groups. Conclusions: The n-3FA use did not contribute to higher perioperative blood loss during spinal arthrodesis.
- Subjects
THERAPEUTIC use of omega-3 fatty acids; HEMORRHAGE; ARTHRODESIS; SURGEONS; NONSTEROIDAL anti-inflammatory agents
- Publication
European Spine Journal, 2012, Vol 21, Issue 12, p2659
- ISSN
0940-6719
- Publication type
Article
- DOI
10.1007/s00586-012-2365-1