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- Title
Role of ferroptosis in acetaminophen-induced hepatotoxicity.
- Authors
Yamada, Naoya; Karasawa, Tadayoshi; Takahashi, Masafumi
- Abstract
Dear Editor, We read with great interest the review article by which Jaeschke et al. ([8]) in which the authors thoroughly reviewed the forms of cell death in acetaminophen (APAP)-induced hepatotoxicity. The review article by Jaeschke et al. pointed out several important issues regarding previous studies that described the role of iron, lipid peroxidation, or ferroptosis in APAP-induced hepatotoxicity (Jaeschke et al. [8]). Furthermore, we provide evidence that auto-oxidation-driven phosphatidylcholine hydroperoxide (PCOOH), a primary product of lipid peroxidation, was increased after APAP treatment, indicating that lipid peroxidation is involved in APAP-induced hepatotoxicity in mice fed a normal chow diet.
- Subjects
HEPATOTOXICOLOGY; OMEGA-6 fatty acids; HYDROPHOBIC compounds; UBIQUINONES; UNSATURATED fatty acids
- Publication
Archives of Toxicology, 2020, Vol 94, Issue 5, p1769
- ISSN
0340-5761
- Publication type
Letter
- DOI
10.1007/s00204-020-02714-5