We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Diffuse (anergic) cutaneous leishmaniasis responding to amphotericin B.
- Authors
Morrison, B.; Mendoza, I.; Delgado, D.; Jaimes, O. Reyes; Aranzazu, N.; Mondolfi, A. E. Paniz
- Abstract
American cutaneous leishmaniasis is an important endemic zoonotic disease in the New World that comprises a spectrum of clinical manifestations. Diffuse cutaneous leishmaniasis (DCL) is a rare form of the disease characterized by antigen-specific immunodeficiency that often presents with multiple disfiguring non-ulcerated confluent nodules or plaques that involve large areas of the skin, resembling lepromatous leprosy. Relapse is invariable in advanced stages, despite aggressive chemotherapy, and a plethora of drugs has been tested with unchanging results. We report on a severe an exceptional case that resolved after treatment with amphotericin B, a drug considered only mildly effective, and discuss the therapeutic approach to this disease.
- Subjects
CASE studies; CUTANEOUS leishmaniasis; HANSEN'S disease; LEPROSTATIC agents; DRUG efficacy; AMPHOTERICIN B; PROGNOSIS; THERAPEUTICS
- Publication
Clinical & Experimental Dermatology, 2010, Vol 35, Issue 4, pe116
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.2009.03737.x