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- Title
Influence of R-CHOP Therapy on Immune System Restoration in Patients with B-Cell Lymphoma.
- Authors
Ito, Kaori; Okamoto, Masataka; Inaguma, Yoko; Okamoto, akinao; ando, Maiko; ando, Yosuke; Tsuge, Masahiro; Tomono, ayana; Kakumae, Yukiko; Hayashi, Takahiro; Yamada, Shigeki; Emi, Nobuhiko
- Abstract
Objective: To assess the immunosuppressive effect of RCHOP in patients with B-cell lymphoma at 2 years. Methods: Parameters of humoral and cell-mediated immunity were assessed in 89 patients with diffuse large B-cell lymphoma or follicular lymphoma before and after 6-8 cycles of R-CHOP-14 or R-CHOP-21 regimen. Results: Data on pre- and posttreatment serum IgG (sIgG) levels were available for all 89 patients, while the corresponding data on serum CD20+, CD3+, CD4+, and CD8+ lymphocyte counts were available in only 43. Median sIgG levels significantly decreased from 1,221 mg/dl (baseline) to 733 mg/dl (after chemotherapy) (p < 0.001). Although CD20+ and CD4+ cell counts decreased (p < 0.001), no significant effect of chemotherapy on CD3+ and CD8+ cell counts was observed. CD20+ cell counts were restored to baseline levels at the 12-month follow-up. sIgG levels and CD4+ cell counts were not completely restored at 24 months, indicating a sustained immunosuppressive effect of R-CHOP in these patients. The incidence of infections over the 2-year period was 16.3-23.6%. Conclusion: The immunosuppressive effect of R-CHOP in newly diagnosed cases of Bcell lymphoma tends to persist for >2 years, although sIgG levels were restored more quickly than CD4+ cell counts.
- Subjects
ANTINEOPLASTIC agents; B cell lymphoma; IMMUNITY; IMMUNOGLOBULINS; IMMUNOSUPPRESSION; INFECTION; LYMPHOCYTES; CYTOMETRY
- Publication
Oncology, 2016, Vol 91, Issue 6, p302
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000449251