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- Title
Effects of Switching from a High-Fat Diet to a Low-Fat Diet on Tumor Proliferation and Cell Kinetics of 7,12-Dimethyl-benz(a)anthracene- Induced Mammary Carcinoma in Rats.
- Authors
Noguchi, Masakuni; Ohta, Nagayoshi; Kitagawa, Hirohisa; Earashi, Mitsumasa; Thomas, Michael; Miyazaki, Itsuo; Mizukami, Yuji
- Abstract
We investigated the stimulatory effect of a high-fat diet on tumorigenesis, tumor proliferation and cell kinetics of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in Sprague-Dawley rats, and sought to determine whether switching the animals from a high-fat diet to a low-fat diet would suppress tumor proliferation and cell kinetics. The high-fat diet significantly stimulated tumorigenesis, tumor proliferation and cell kinetics. After the animals were switched from the high-fat diet to the low-fat diet, however, tumor growth decreased, the BrdUrd labeling indices of tumors significantly decreased, and the potential doubling times of tumors significantly increased. Therefore, switching from a high-fat diet to a low-fat diet may improve the prognosis of breast cancer. Copyright © 1992 S. Karger AG, Basel
- Publication
Oncology, 1992, Vol 49, Issue 3, p246
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000227049