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- Title
Clinicoprognostic Study of Hydroa Vacciniforme-like Lymphoproliferative Diseases: A Systematic Review.
- Authors
Kim, Young Jae; Yang, Hee Joo; Won, Chong Hyun; Chang, Sung Eun; Lee, Mi Woo; Lee, Woo Jin
- Abstract
Background: Limited clinicopathological and prognostic data are available on hydroa vacciniforme (HV)-like lymphoproliferative diseases (HVLPD). Methods: This systematic review searched HVLPD reports in Medline via PubMed, Embase, Cochrane, and CINAHL databases in October 2020. Results: A total of 393 patients (65 classic HV, 328 severe HV/HV-like T-cell lymphoma [HVLL]) were analyzed. Among severe HV/HVLL cases, 56.0% were Asians, whereas 3.1% were Caucasians. Facial edema, hypersensitivity to mosquito bites, the onset of skin lesion, and percentage of severe HV/HVLL differed significantly by race. Progression to systemic lymphoma was confirmed in 9.4% of HVLPD patients. Death occurred in 39.7% patients with severe HV/HVLL. Facial edema was the only risk factor associated with progression and overall survival. Mortality risk was higher in Latin Americans than in Asians and Caucasians. CD4/CD8 double-negativity was significantly associated with the worst prognosis and increased mortality. Conclusion: HVLPD is a heterogeneous entity with variable clinicopathological features associated with genetic predispositions.
- Subjects
LYMPHOPROLIFERATIVE disorders; CINAHL database; T-cell lymphoma; OVERALL survival; LATIN Americans
- Publication
Dermatology (10188665), 2023, Vol 239, Issue 5, p700
- ISSN
1018-8665
- Publication type
Article
- DOI
10.1159/000530607