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- Title
The heterogeneity of the germinative compartment in human epidermis and its implications in pathogenesis.
- Authors
Laporte, M.; Heenen, M.
- Abstract
In mouse epidermis keratinocytes of the basal layer seem to belong to 3 different subpopulations: stem cells, transit cells and postmitotic cells. Each subpopulation assumes a specific role in epidermal homeostasis. Recent data tend to display a similar heterogeneity among basal keratinocytes in human epidermis. This concept opens the door to an integrated understanding of epidermal renewal but also suggests new hypotheses in pathogenesis. Psoriasis, a typical example of epidermal hyperplasia, is considered from this point of view.
- Publication
Dermatology (10188665), 1994, Vol 189, Issue 4, p340
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000246875