We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Progressive hyperpigmentation: case report with a clinical, histological, and ultrastructural investigation.
- Authors
Betts, C.M.; Bardazzi, F.; Fanti, P.A.; Tosti, A.; Varotti, C.
- Abstract
A clinical, histological and ultrastructural study of a 38-year-old woman with generalized progressive hyperpigmentation is reported. Hyperpigmentation started in early infancy, progressed during childhood and has increased to a dark bronze-brown color with 'mottling' in the last 8 years. Histology and electron microscopy revealed epidermal hypermelanosis and 'negroid' distribution of melanosomes in keratinocytes. In our family, autosomal dominant phenotype transmission with 'variable expression' is suggested. The literature on the entity has been reviewed. This case is another rare example of familial progressive hyperpigmentation.
- Subjects
ELECTRON microscopy; EPIDERMIS; EPITHELIAL cells; GENEALOGY; GENES; GENETIC techniques; KERATINOCYTES; MELANINS; MELANOSIS; PHENOTYPES; LENTIGO; HYPERPIGMENTATION
- Publication
Dermatology (10188665), 1994, Vol 189, Issue 4, p384
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000246885