We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of in vivo Ischemia on Contractile Responses of Rabbit Bladder to Field Stimulation, Carbachol, ATP and KCl.
- Authors
Bratslavsky, Gennady; Whitbeck, Catherine; Horan, Pat; Levin, Robert M.
- Abstract
Rabbits were subjected to bilateral ischemia for 3, 6, or 18 h then euthanized and their bladders excised. Isolated strips of rabbit bladder detrusor were incubated in normal Tyrode’s solution and contractile responses to FS, carbachol, ATP, and KCl measured. Maximal contraction, maximal rate of tension generation, and length of time to maximal contraction were determined. These studies revealed that contractile responses to FS (neurogenic stimulation) were most affected by ischemia. Contractile responses to carbachol, ATP and KCl were all similarly sensitive to ischemia.
- Subjects
ISCHEMIA; LABORATORY rabbits; REPERFUSION injury; MUSCLE contraction; CONTRACTILITY (Biology); MUSCLE tone; SMOOTH muscle; NEURAL stimulation
- Publication
Pharmacology, 1999, Vol 59, Issue 4, p221
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000028323