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- Title
Anti-Tumor Effect of Angiogenesis Inhibitor TNP-470 on the Human Nasopharyngeal Carcinoma Cell Line NPC/HK1.
- Authors
Qian, Chao-Nan; Min, Hua-Qing; Lin, Han-Liang; Feng, Gong-Kan; Ye, Yan-Li; Wang, Lian-Gui; Kuang, Zhu-Ji
- Abstract
The efficacy and targeting cells of angiogenesis inhibitor TNP-470 on human squamous cell nasopharyngeal carcinoma (NPC) were investigated. The colorimetric MTT assay was used to evaluate the IC[sub 50] values of NPC/HK1 cells and human dermal microvascular endothelial cells (HDMEC) for TNP-470. An NPC human tumor model was built by tumor-bearing nude mice using the NPC cell line of NPC/HK1. TNP-470 (30 mg/kg s.c.) was injected every other day. The results showed that the IC[sub 50] of NPC/HK1 cells for TNP-470 was 3.8 times higher than that of HDMEC. A significant difference in tumor volume between control and treatment groups was found after 7 days of treatment and increased thereafter. At the end of the treatment, tumor volume was 773.7 ± 287.1 mm[sup 3] (n = 8) in the control group versus 454.5 ± 132.8 mm[sup 3] (n = 8) in the treatment group (p = 0.013); the ratio of the mean tumor volume in treated animals to that of control animals was 0.587, resulting a 41.3% decrease in tumor growth. The necrotic area was larger in the treatment group. Physical toxicity did not result from the treatment. These studies suggest that angiogenesis inhibitor TNP-470 is effective in the treatment of squamous cell NPC without obvious toxicity.
- Subjects
NEOVASCULARIZATION inhibitors; NASOPHARYNX cancer; CANCER; TUMORS; CELL lines
- Publication
Oncology, 1999, Vol 57, Issue 1, p36
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000011998