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- Title
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
- Authors
Heneka, Michael T.; Kummer, Markus P.; Stutz, Andrea; Delekate, Andrea; Schwartz, Stephanie; Vieira-Saecker, Ana; Griep, Angelika; Axt, Daisy; Remus, Anita; Tzeng, Te-Chen; Gelpi, Ellen; Halle, Annett; Korte, Martin; Latz, Eicke; Golenbock, Douglas T.
- Abstract
Alzheimer's disease is the world's most common dementing illness. Deposition of amyloid-? peptide drives cerebral neuroinflammation by activating microglia. Indeed, amyloid-? activation of the NLRP3 inflammasome in microglia is fundamental for interleukin-1? maturation and subsequent inflammatory events. However, it remains unknown whether NLRP3 activation contributes to Alzheimer's disease in vivo. Here we demonstrate strongly enhanced active caspase-1 expression in human mild cognitive impairment and brains with Alzheimer's disease, suggesting a role for the inflammasome in this neurodegenerative disease. Nlrp3?/? or Casp1?/? mice carrying mutations associated with familial Alzheimer's disease were largely protected from loss of spatial memory and other sequelae associated with Alzheimer's disease, and demonstrated reduced brain caspase-1 and interleukin-1? activation as well as enhanced amyloid-? clearance. Furthermore, NLRP3 inflammasome deficiency skewed microglial cells to an M2 phenotype and resulted in the decreased deposition of amyloid-? in the APP/PS1 model of Alzheimer's disease. These results show an important role for the NLRP3/caspase-1 axis in the pathogenesis of Alzheimer's disease, and suggest that NLRP3 inflammasome inhibition represents a new therapeutic intervention for the disease.
- Subjects
GENES; AMYLOID; GLYCOPROTEINS; MICROGLIA; ALZHEIMER'S disease treatment; MILD cognitive impairment; PHYSIOLOGY; THERAPEUTICS
- Publication
Nature, 2013, Vol 493, Issue 7434, p674
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature11729