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- Title
Functional Interactions between Biogenic Amines, 3′,5′-cyclic AMP and Manganese.
- Authors
PAPAVASILIOU, PAUL S.; MILLER, SAMUEL T.; COTZIAS, GEORGE C.
- Abstract
THE similarities between the dysfunctions of Parkinsonism and chronic manganese poisoning have been noted earlier1,2. Evidence has recently suggested that subjects with either of these diseases could have diminished cerebral concentrations of dopamine: dihydroxyphenylalanine (DOPA) has ameliorated Parkinsonians3 in whom diminution of striatal dopamine is an established fact4. The same amino-acid has lessened the rigidity of individuals with chronic manganism1,3, and so it is thought that in these cases, too, there must be a low concentration of dopamine in the brain: DOPA is an immediate precursor of dopamine.
- Publication
Nature, 1968, Vol 220, Issue 5162, p74
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/220074a0