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- Title
Features of Interaction of Lysozyme with PGLU–PEG Block Copolymers.
- Authors
Filatova, L. Yu.; Balabushevich, N. G.
- Abstract
The interaction of hen egg white lysozyme and block copolymers of poly(L–glutamic acid sodium salt) and polyethylene glycol (PGLU10–PEG and PGLU100–PEG) have been studied in an aqueous medium and at a water–air interface. Different physicochemical methods have been used: turbidimetry, tensiometry, fluorimetry, circular dichroism spectroscopy, electrophoretic light scattering, and transmission electron microscopy. The formation of mixed adsorption layers at the water–air interface has been observed at block copolymer : enzyme molar ratios of at most 2 : 1. In an aqueous medium, complexation of lysozyme with PGLU–PEG block copolymers leads to the formation of core–shell PGLU10–PEG : lysozyme complexes and PGLU100–PEG : lysozyme complexes with molar compositions of 1 : 1 or 2 : 1. The possibility of regulating the properties of the enzyme–block copolymer interaction products makes it possible to develop strategies for the production of antibacterial drugs.
- Subjects
LYSOZYMES; BLOCK copolymers; GLUTAMIC acid; CIRCULAR dichroism; TRANSMISSION electron microscopy; POLYETHYLENE glycol; SODIUM salts; LIGHT scattering
- Publication
Colloid Journal, 2024, Vol 86, Issue 2, p287
- ISSN
1061-933X
- Publication type
Article
- DOI
10.1134/S1061933X23601336