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- Title
Organic ligand l-(l-morpholino-l- (thiophen-2-yl) ethyl)-3-phenylurea: Synthesis, Characterization, Derivatives and Exploration of Bioactivity.
- Authors
Kannan, S.; Gomathi, A.; Padusha, M. Syed Ali; Satheesh, Dhurairaj
- Abstract
Organic compounds possessing a comparatively greater number of nitrogens, fascinating attention in the upcoming field of medicine and its research. Synthesizing new drugs with a greater number of nitrogen atoms in their structure skeleton place challenges. Unique feature say lipophilicity carried by Mannich bases and their bivalent metal coordination complexes claim themselves to be potential sources [1-3]. Heterocyclic organic compounds rooted through amines and amides possess enhanced absorption through bio-membranes because of its lipohilicity which results in boundless pharmaceutical applications [4-11]. They considerably shorten the duration of therapy too. Mannich base and its coordination complexes with a range of first transition bivalent metals, such as, Co2+' Mn2+, Ni2+, Cu2+ and Zn2+ are reported along with DPPH free radical scavenging activity and anti-inflammatory activity. The scheme sequenced with 2-acetylthiophene, morpholine and phenyl urea was not yet described, the new Mannich base, l-(l-morpholino-l-(thiophen-2-yl) ethyl)-3-phenylurea (L), was synthesized. The compound and all the complexes were characterized.
- Subjects
ORGANIC compounds; LIGANDS (Chemistry); NITROGEN; ABSORPTION; LIPOPHILICITY
- Publication
Mapana Journal of Sciences, 2023, Vol 22, Issue 3, p119
- ISSN
0975-3303
- Publication type
Article
- DOI
10.12723/mjs.66.6