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- Title
Low transition temperature mixtures prompted one-pot synthesis of 5, 10 dihydropyrimido[4,5-b]quinoline-2,4(1 H,3 H)-dione derivatives.
- Authors
Mohire, Priyanka; Patil, Reshma; Chandam, Dattatraya; Jadhav, Sunetra; Patravale, Ajinkya; Kumbhar, Digambar; Ghosh, Jai; Deshmukh, Madhukar
- Abstract
An efficient green protocol has been investigated for the synthesis of pyrimido[4,5-b]quinolines derivatives via one-pot three-component condensation of 4-chloro aniline, aromatic aldehyde and barbituric acid using low transition temperature mixtures as new generation and sustainable solvents. The process was accomplished with the use of greener and recyclable reaction media, simple methodology, easy workup procedures and no chromatographic purification with high yield. This new approach is expected to discover some significance in combinatorial synthesis of biologically active scaffolds. Graphical Abstract:
- Subjects
QUINOLINE derivatives; CONDENSATION; CHLOROANILINE; TRANSITION temperature; CHROMATOGRAPHIC analysis
- Publication
Research on Chemical Intermediates, 2017, Vol 43, Issue 12, p7013
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-017-3033-1