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- Title
The mechanobiology of brain function.
- Authors
Tyler WJ; Tyler, William J
- Abstract
All cells are influenced by mechanical forces. In the brain, force-generating and load-bearing proteins twist, turn, ratchet, flex, compress, expand and bend to mediate neuronal signalling and plasticity. Although the functions of mechanosensitive proteins have been thoroughly described in classical sensory systems, the effects of endogenous mechanical energy on cellular function in the brain have received less attention, and many working models in neuroscience do not currently integrate principles of cellular mechanics. An understanding of cellular-mechanical concepts is essential to allow the integration of mechanobiology into ongoing studies of brain structure and function.
- Publication
Nature Reviews Neuroscience, 2012, Vol 13, Issue 11, p867
- ISSN
1471-003X
- Publication type
research
- DOI
10.1038/nrn3383